The Valley of the Temples is the best-preserved Greek temple complex outside Athens. The Temple of Concordia alone justifies crossing Sicily. About 2.5 hours from Catania.
SAIS from Catania Piazza Papa Giovanni XXIII, direct. Then local bus 1/2/3 to the temples (15 min, €1.20).
SS640 + SS626 through interior Sicily. Dramatic landscape — vast wheat fields, hilltop towns.
Bus if carless, car if you have one. Full day needed — temples need 3+ hours, museum adds context.