Eat
Sciascia Caffè (the best coffee in Rome — since 1919), Romeo Chef & Baker (Cristina Bowerman's modern Italian), Il Sorpasso (all-day bistro, excellent aperitivo), Non Solo Pizza (hidden gem pizza al taglio).
Drink
Passaguai (natural wine, tapas vibes), Sciascia Caffè (their chocolate-rimmed espresso is legendary), wine bars on Via Cola di Rienzo.
See
Vatican Museums and St Peter's (obviously — Prati is the closest neighbourhood). Castel Sant'Angelo (Hadrian's mausoleum, rooftop bar with views). Via Cola di Rienzo is Rome's best non-touristy shopping street.
Shop
Via Cola di Rienzo for Italian brands at local prices (no tourist markup). Castroni (legendary deli — imported foods, Italian specialties, great gifts). Via Ottaviano for food shops.
Why this neighbourhood?
Every great Italy trip includes at least one neighbourhood where you stop sightseeing and start living. This could be yours.